If Jurgen Klopp's men are to end their winless run of six Premier League games, they must beat fierce rivals Manchester United in Saturday's early kick off.
Liverpool:
The Reds will have to make do without last season's top scorer Sadio Mane, who suffered a hamstring injury while on international duty with Senegal last weekend.
Philippe Coutinho and Roberto Firmino will have had just two days to prepare with their teammates as they had to complete a 6,000-mile journey from Sao Paulo following the international break.
Alex Oxlade-Chamberlain could use the fixture to kick-start his Liverpool career. He has started just one game since his summer arrival from Arsenal, coming in the EFL Cup defeat to Leicester City.
Long-term absentees Adam Lallana and Nathaniel Clyne remain sidelined with a thigh injury and a back issue respectively.
Manchester United:
United will also be without two of their most influential players, Marouane Fellaini and Paul Pogba, who are both sidelined with injuries.
The positive news for Mourinho, however, is that star striker Romelu Lukaku should be fit to start after overcoming an ankle issue.
Who will start on the left flank? Take a look at the comparison between Marcus Rashford and Anthony Martial here.
Phil Jones is a doubt after withdrawing from the England squad with an injury, while Marcos Rojo and Zlatan Ibrahimovic (both knee) continue to recover from their injuries.
Possible lineups:
Liverpool: Mignolet; A.Arnold, Matip, Lovren, Moreno; Can, Henderson, Oxlade-Chamberlain; Salah, Firmino, Coutinho
Manchester United: De Gea; Valencia, Smalling, Bailly, Blind; Herrera, Matic, Mata, Mkhitaryan, Rashford; Lukaku