Ajax centre-back Davinson Sanchez starred for the Dutch side, scoring six goals in his first season in the Eredivisie and helping carry his team to the Europa League final.
After impressing many of Europe's top clubs, including Barcelona, Sanchez is poised to leave Amsterdam, and north London could the destination for the 21-year-old.
Pochettino is understood to also be in the market for a right-back, a midfielder and a forward, but the former Atletico Nacional man is his preferred option for central defence.