The Belgian defender has been struggling with a minor ankle problem in the past few weeks and he was left out of Belgium's 3-3 draw against Mexico last week.
He did play in the 1-0 win over Japan on Tuesday night and came away unscathed and he has provided Mauricio Pochettino with a major boost ahead of the clash with Arsenal.
"Yeah, nothing to worry about," Vertonghen said after the match in Bruges. I've been struggling for two weeks with it and that's why I didn't play against West Ham in the Carabao Cup but all good, I feel very good today, I am ready for the weekend."
With the international break now over, the 30-year-old can now turn his attention to Tottenham's trip to the Emirates Stadium on Saturday, where he is hoping for his first ever away win against Tottenham's bitter local rivals.
He added: "I can't recall I've won at the Emirates so that's what we're going for this weekend.
"Obviously we're doing well with Spurs, Arsenal as well, and it will be a good game.They are always good games, always positive games, always respect between us, two positives sides who make good games."