It was described pre-match as the biggest game of the English club's season, but with just two minutes gone Spurs found themselves behind in Turin.
A sloppy piece of defending gave the hosts an early free-kick and Miralem Pjanic deftly dinked the ball into the path of Higuain, who volleyed past Hugo Lloris first time on the turn from the edge of the box.
It was a fine finish, with the Juventus faithful barely able to contain their excitement.
Check out the strike for yourself below:
13 February 2018